CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia

We investigated cell cycle regulation in acute myeloid leukemia cells expressing the FLT3-ITD mutated tyrosine kinase receptor, an underexplored field in this disease. Upon FLT3 inhibition, CDC25A mRNA and protein were rapidly down-regulated, while levels of other cell cycle proteins remained unchan...

Descripción completa

Detalles Bibliográficos
Autores principales: Bertoli, Sarah, Boutzen, Helena, David, Laure, Larrue, Clément, Vergez, François, Fernandez-Vidal, Anne, Yuan, Lingli, Hospital, Marie-Anne, Tamburini, Jérôme, Demur, Cécile, Delabesse, Eric, Saland, Estelle, Sarry, Jean-Emmanuel, Galcera, Marie-Odile, Mas, Véronique Mansat-De, Didier, Christine, Dozier, Christine, Récher, Christian, Manenti, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741984/
https://www.ncbi.nlm.nih.gov/pubmed/26515730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741984/
https://www.ncbi.nlm.nih.gov/pubmed/26515730

Ejemplares similares