Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries

Intestinal stem cell (ISC) self-renewal and proliferation are directed by Wnt/β-catenin signaling in mammals, whereas aberrant Wnt pathway activation in ISCs triggers the development of human colorectal carcinoma. Herein, we have utilized the Drosophila midgut, a powerful model for ISC regulation, t...

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Detalles Bibliográficos
Autores principales: Tian, Ai, Benchabane, Hassina, Wang, Zhenghan, Ahmed, Yashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742051/
https://www.ncbi.nlm.nih.gov/pubmed/26845150
http://dx.doi.org/10.1371/journal.pgen.1005822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742051/
https://www.ncbi.nlm.nih.gov/pubmed/26845150
http://dx.doi.org/10.1371/journal.pgen.1005822

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