c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells

Mesenchymal stem cells (MSCs) are therapeutically relevant multilineage and immunomodulatory progenitors. Ex vivo expansion of these rare cells is necessary for clinical application and can result in detrimental senescent effects, with mechanisms still largely unknown. We found that vigorous ex vivo...

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Detalles Bibliográficos
Autores principales: Chen, Pei-Min, Lin, Chia-Hua, Li, Nan-Ting, Wu, Yao-Ming, Lin, Ming-Tsan, Hung, Shih-Chieh, Yen, Men-Luh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742114/
https://www.ncbi.nlm.nih.gov/pubmed/26496036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742114/
https://www.ncbi.nlm.nih.gov/pubmed/26496036

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