Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design

Chk1 kinase is a critical component of the DNA damage response checkpoint especially in cancer cells and targeting Chk1 is a potential therapeutic opportunity for potentiating the anti-tumor activity of DNA damaging chemotherapy drugs. Fragment elaboration by structure guided design was utilized to...

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Detalles Bibliográficos
Autores principales: Massey, Andrew J., Stokes, Stephen, Browne, Helen, Foloppe, Nicolas, Fiumana, Andreá, Scrace, Simon, Fallowfield, Mandy, Bedford, Simon, Webb, Paul, Baker, Lisa, Christie, Mark, Drysdale, Martin J., Wood, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742142/
https://www.ncbi.nlm.nih.gov/pubmed/26437226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742142/
https://www.ncbi.nlm.nih.gov/pubmed/26437226

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