Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling

ADAM10 (A Disintegrin and Metalloprotease Domain 10) affects the pathophysiology of various cancers, and we had shown that inhibition of ADAM10 sensitizes pancreatic cancer cells to gemcitabine. ADAM10 is activated in response to calcium influx, and here we examined if calcium channel blockers (CCB)...

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Detalles Bibliográficos
Autores principales: Woods, Neha, Trevino, Jose, Coppola, Domenico, Chellappan, Srikumar, Yang, Shengyu, Padmanabhan, Jaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742152/
https://www.ncbi.nlm.nih.gov/pubmed/26440150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742152/
https://www.ncbi.nlm.nih.gov/pubmed/26440150

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