Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin

High-grade conventional osteosarcoma is the most common primary bone tumor. Prognosis for osteosarcoma patients is poor and resistance to chemotherapy is common. We performed an siRNA screen targeting members of the Bcl-2 family in human osteosarcoma cell lines to identify critical regulators of ost...

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Detalles Bibliográficos
Autores principales: Baranski, Zuzanna, de Jong, Yvonne, Ilkova, Trayana, Peterse, Elisabeth F.P., Cleton-Jansen, Anne-Marie, van de Water, Bob, Hogendoorn, Pancras C.W., Bovée, Judith V.M.G., Danen, Erik H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742165/
https://www.ncbi.nlm.nih.gov/pubmed/26416351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742165/
https://www.ncbi.nlm.nih.gov/pubmed/26416351

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