Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1

The effectiveness of Hsp90 inhibitors as anticancer agents was limited in multidrug-resistant (MDR) human cancer cells due to induction of heat shock proteins (Hsps) such as Hsp70/Hsp27 and P-glycoprotein (P-gp)-mediated efflux. In the present study, we showed that resistance to Hsp90 inhibitors of...

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Detalles Bibliográficos
Autores principales: Kim, Hak-Bong, Lee, Su-Hoon, Um, Jee-Hyun, Oh, Won Keun, Kim, Dong-Wan, Kang, Chi-Dug, Kim, Sun-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742171/
https://www.ncbi.nlm.nih.gov/pubmed/26416354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742171/
https://www.ncbi.nlm.nih.gov/pubmed/26416354

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