Cargando…
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1
The effectiveness of Hsp90 inhibitors as anticancer agents was limited in multidrug-resistant (MDR) human cancer cells due to induction of heat shock proteins (Hsps) such as Hsp70/Hsp27 and P-glycoprotein (P-gp)-mediated efflux. In the present study, we showed that resistance to Hsp90 inhibitors of...
Autores principales: | Kim, Hak-Bong, Lee, Su-Hoon, Um, Jee-Hyun, Oh, Won Keun, Kim, Dong-Wan, Kang, Chi-Dug, Kim, Sun-Hee |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742171/ https://www.ncbi.nlm.nih.gov/pubmed/26416354 |
Ejemplares similares
-
Sensitization of Chemo-Resistant Human Chronic Myeloid Leukemia Stem-Like Cells to Hsp90 Inhibitor by SIRT1 Inhibition
por: Kim, Hak-Bong, et al.
Publicado: (2015) -
Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death
por: Moon, Hyun-Jung, et al.
Publicado: (2018) -
Nonsteroidal Anti-inflammatory Drugs Sensitize CD44-Overexpressing Cancer Cells to Hsp90 Inhibitor Through Autophagy Activation
por: Moon, Hyun-Jung, et al.
Publicado: (2019) -
TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases
por: Seo, Suk-Bin, et al.
Publicado: (2010) -
Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and C. elegans
por: Nguyen, Minh Tu, et al.
Publicado: (2018)