Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells

Tyrosine kinase inhibitors (TKIs) including axitinib have been introduced in the treatment of renal cell carcinoma (RCC) because of their anti-angiogenic properties. However, no evidence are presently available on a direct cytotoxic anti-tumor activity of axitinib in RCC. Herein we reported by weste...

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Detalles Bibliográficos
Autores principales: Morelli, Maria Beatrice, Amantini, Consuelo, Santoni, Matteo, Soriani, Alessandra, Nabissi, Massimo, Cardinali, Claudio, Santoni, Angela, Santoni, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742174/
https://www.ncbi.nlm.nih.gov/pubmed/26474283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742174/
https://www.ncbi.nlm.nih.gov/pubmed/26474283

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