TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo

Glioblastoma is the most frequent primary brain tumor in adults. Current therapeutic options are sparse and the prognosis of patients suffering from this disease is grim. Abundance in intratumoral heterogeneity among different deregulated signaling pathways is a hallmark of glioblastoma and likely a...

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Detalles Bibliográficos
Autores principales: Karpel-Massler, Georg, Bâ, Maïmouna, Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742189/
https://www.ncbi.nlm.nih.gov/pubmed/26474387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742189/
https://www.ncbi.nlm.nih.gov/pubmed/26474387

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