Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors

Severe dengue is caused by host responses to viral infection, but the pathogenesis remains unknown. This is, in part, due to the lack of suitable animal models. Here, we report a non-mouse-adapted low-passage DENV-3 clinical isolate, DV3P12/08, derived from recently infected patients. DV3P12/08 caus...

Descripción completa

Detalles Bibliográficos
Autores principales: Phanthanawiboon, Supranee, Limkittikul, Kriengsak, Sakai, Yusuke, Takakura, Nobuyuki, Saijo, Masayuki, Kurosu, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742241/
https://www.ncbi.nlm.nih.gov/pubmed/26844767
http://dx.doi.org/10.1371/journal.pone.0148564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742241/
https://www.ncbi.nlm.nih.gov/pubmed/26844767
http://dx.doi.org/10.1371/journal.pone.0148564

Ejemplares similares