Mycobacterium tuberculosis WhiB3 Responds to Vacuolar pH-induced Changes in Mycothiol Redox Potential to Modulate Phagosomal Maturation and Virulence

The ability of Mycobacterium tuberculosis to resist intraphagosomal stresses, such as oxygen radicals and low pH, is critical for its persistence. Here, we show that a cytoplasmic redox sensor, WhiB3, and the major M. tuberculosis thiol, mycothiol (MSH), are required to resist acidic stress during i...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehta, Mansi, Rajmani, Raju S., Singh, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742752/
https://www.ncbi.nlm.nih.gov/pubmed/26637353
http://dx.doi.org/10.1074/jbc.M115.684597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742752/
https://www.ncbi.nlm.nih.gov/pubmed/26637353
http://dx.doi.org/10.1074/jbc.M115.684597

Ejemplares similares