Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation

Nonalcoholic fatty liver disease (NAFLD) associates with obesity and type 2 diabetes. Hypoactive AMP-activated protein kinase (AMPK), hyperactive mammalian target of rapamycin (mTOR) signaling, and macrophage-mediated inflammation are mechanistically linked to NAFLD. Studies investigating roles of a...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Rajapakse, Angana G., Riedo, Erwin, Fellay, Benoit, Bernhard, Marie-Claire, Montani, Jean-Pierre, Yang, Zhihong, Ming, Xiu-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742779/
https://www.ncbi.nlm.nih.gov/pubmed/26846206
http://dx.doi.org/10.1038/srep20405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742779/
https://www.ncbi.nlm.nih.gov/pubmed/26846206
http://dx.doi.org/10.1038/srep20405

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