Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways

In this study, we investigated the effects of miltirone in human leukemia cell lines, primary leukemia cells, and nude mice U937 xenograft. Treatment of cells with miltirone resulted in apoptosis, mitochondria membrane potential (MMP) collapses, increase of Bax/Bcl-2 ratio, and cytochrome c release....

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Detalles Bibliográficos
Autores principales: Zhou, Ling, Jiang, Lifeng, Xu, Maolei, Liu, Qun, Gao, Ning, Li, Ping, Liu, E-Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742825/
https://www.ncbi.nlm.nih.gov/pubmed/26848099
http://dx.doi.org/10.1038/srep20585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742825/
https://www.ncbi.nlm.nih.gov/pubmed/26848099
http://dx.doi.org/10.1038/srep20585

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