Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells

STAT3 regulates the expansion of myeloid-derived suppressor cells (MDSCs) during inflammation, infection and cancer. Hyperactivation of STAT3 in gp130(757F/F) mice is associated with protection from experimental colitis. This study determined mechanisms for this protection and compared this to mice...

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Detalles Bibliográficos
Autores principales: Däbritz, Jan, Judd, Louise M., Chalinor, Heather V., Menheniott, Trevelyan R., Giraud, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742831/
https://www.ncbi.nlm.nih.gov/pubmed/26848037
http://dx.doi.org/10.1038/srep20584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742831/
https://www.ncbi.nlm.nih.gov/pubmed/26848037
http://dx.doi.org/10.1038/srep20584

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