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Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells

STAT3 regulates the expansion of myeloid-derived suppressor cells (MDSCs) during inflammation, infection and cancer. Hyperactivation of STAT3 in gp130(757F/F) mice is associated with protection from experimental colitis. This study determined mechanisms for this protection and compared this to mice...

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Detalles Bibliográficos
Autores principales:	Däbritz, Jan, Judd, Louise M., Chalinor, Heather V., Menheniott, Trevelyan R., Giraud, Andrew S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742831/ https://www.ncbi.nlm.nih.gov/pubmed/26848037 http://dx.doi.org/10.1038/srep20584

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