Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

In soft tissue sarcomas (STS), low intratumoural O(2) (hypoxia) is a poor prognostic indicator. HIF-1α mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2α protein is unknown. Surprisingly, here we show that HIF-2α inhibits high-grad...

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Detalles Bibliográficos
Autores principales: Nakazawa, Michael S., Eisinger-Mathason, T. S. Karin, Sadri, Navid, Ochocki, Joshua D., Gade, Terence P. F., Amin, Ruchi K., Simon, M. Celeste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742834/
https://www.ncbi.nlm.nih.gov/pubmed/26837714
http://dx.doi.org/10.1038/ncomms10539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742834/
https://www.ncbi.nlm.nih.gov/pubmed/26837714
http://dx.doi.org/10.1038/ncomms10539

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