Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin

Streptonigrin is a potent antitumor antibiotic, active against a wide range of mammalian tumor cells. It was reported that its biosynthesis relies on (2S,3R)-β-methyltryptophan as an intermediate. In this study, the biosynthesis of (2S,3R)-β-methyltryptophan and its isomer (2S,3S)-β-methyltryptophan...

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Detalles Bibliográficos
Autores principales: Kong, Dekun, Zou, Yi, Zhang, Zhang, Xu, Fei, Brock, Nelson L., Zhang, Liping, Deng, Zixin, Lin, Shuangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742848/
https://www.ncbi.nlm.nih.gov/pubmed/26847951
http://dx.doi.org/10.1038/srep20273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742848/
https://www.ncbi.nlm.nih.gov/pubmed/26847951
http://dx.doi.org/10.1038/srep20273

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