Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

Topoisomerase 1, an enzyme that relieves superhelical tension, is implicated in transcription-associated mutagenesis and genome instability-associated with neurodegenerative diseases as well as activation-induced cytidine deaminase. From proteomic analysis of TOP1-associated proteins, we identify SM...

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Detalles Bibliográficos
Autores principales: Husain, Afzal, Begum, Nasim A., Taniguchi, Takako, Taniguchi, Hisaaki, Kobayashi, Maki, Honjo, Tasuku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742980/
https://www.ncbi.nlm.nih.gov/pubmed/26842758
http://dx.doi.org/10.1038/ncomms10549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742980/
https://www.ncbi.nlm.nih.gov/pubmed/26842758
http://dx.doi.org/10.1038/ncomms10549

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