Structural basis of complement membrane attack complex formation

In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit' mechanism; however, sublytic MAC pores on host cells activate signalling pathways. Previous studies have des...

Descripción completa

Detalles Bibliográficos
Autores principales: Serna, Marina, Giles, Joanna L., Morgan, B. Paul, Bubeck, Doryen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743022/
https://www.ncbi.nlm.nih.gov/pubmed/26841837
http://dx.doi.org/10.1038/ncomms10587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743022/
https://www.ncbi.nlm.nih.gov/pubmed/26841837
http://dx.doi.org/10.1038/ncomms10587

Ejemplares similares