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Structural basis of complement membrane attack complex formation

In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit' mechanism; however, sublytic MAC pores on host cells activate signalling pathways. Previous studies have des...

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Detalles Bibliográficos
Autores principales:	Serna, Marina, Giles, Joanna L., Morgan, B. Paul, Bubeck, Doryen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743022/ https://www.ncbi.nlm.nih.gov/pubmed/26841837 http://dx.doi.org/10.1038/ncomms10587

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