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Structural basis for human PRDM9 action at recombination hot spots

The multidomain zinc finger (ZnF) protein PRDM9 (PRD1–BF1–RIZ1 homologous domain-containing 9) is thought to influence the locations of recombination hot spots during meiosis by sequence-specific DNA binding and trimethylation of histone H3 Lys4. The most common variant of human PRDM9, allele A (hPR...

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Detalles Bibliográficos
Autores principales:	Patel, Anamika, Horton, John R., Wilson, Geoffrey G., Zhang, Xing, Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743056/ https://www.ncbi.nlm.nih.gov/pubmed/26833727 http://dx.doi.org/10.1101/gad.274928.115

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