A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling

Senescence stimuli activate multiple tumor suppressor pathways to initiate cycle arrest and a differentiation program characteristic of senescent cells. We performed a two-stage, gain-of-function screen to select for the genes whose enhanced expression can bypass replicative senescence. We uncovered...

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Detalles Bibliográficos
Autores principales: Wang, Yifan, Xu, Qikai, Sack, Laura, Kang, Chanhee, Elledge, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743059/
https://www.ncbi.nlm.nih.gov/pubmed/26833729
http://dx.doi.org/10.1101/gad.271445.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743059/
https://www.ncbi.nlm.nih.gov/pubmed/26833729
http://dx.doi.org/10.1101/gad.271445.115

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