c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

BACKGROUND: Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and ability to sequester TNF-receptor associated factor 2 (TRAF2) and c-Jun N-termina...

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Detalles Bibliográficos
Autores principales: Palumbo, Camilla, De Luca, Anastasia, Rosato, Nicola, Forgione, Mariantonietta, Rotili, Dante, Caccuri, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743117/
https://www.ncbi.nlm.nih.gov/pubmed/26847645
http://dx.doi.org/10.1186/s12967-016-0796-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743117/
https://www.ncbi.nlm.nih.gov/pubmed/26847645
http://dx.doi.org/10.1186/s12967-016-0796-x

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