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c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
BACKGROUND: Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and ability to sequester TNF-receptor associated factor 2 (TRAF2) and c-Jun N-termina...
Autores principales: | Palumbo, Camilla, De Luca, Anastasia, Rosato, Nicola, Forgione, Mariantonietta, Rotili, Dante, Caccuri, Anna Maria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743117/ https://www.ncbi.nlm.nih.gov/pubmed/26847645 http://dx.doi.org/10.1186/s12967-016-0796-x |
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