Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning

BACKGROUND: The human ATP binding cassette transporters Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (P-gp) are co-expressed in many tissues and barriers, especially at the blood–brain barrier and at the hepatocyte canalicular membrane. Understanding their interplay in...

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Detalles Bibliográficos
Autores principales: Montanari, Floriane, Zdrazil, Barbara, Digles, Daniela, Ecker, Gerhard F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743411/
https://www.ncbi.nlm.nih.gov/pubmed/26855674
http://dx.doi.org/10.1186/s13321-016-0121-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743411/
https://www.ncbi.nlm.nih.gov/pubmed/26855674
http://dx.doi.org/10.1186/s13321-016-0121-y

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