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Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus

AIMS: Serum cystatin C (CysC) has recently been shown to be associated with the incidence of type 2 diabetes mellitus (T2DM) and progression to the pre-diabetic state. The aim of this study was to explore the relationship between serum CysC and the risk of gestational diabetes mellitus (GDM) in Chin...

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Autores principales: Zhao, Weijing, Pan, Jiemin, Li, Huaping, Huang, Yajuan, Liu, Fang, Tao, Minfang, Jia, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743926/
https://www.ncbi.nlm.nih.gov/pubmed/26849560
http://dx.doi.org/10.1371/journal.pone.0147277
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author Zhao, Weijing
Pan, Jiemin
Li, Huaping
Huang, Yajuan
Liu, Fang
Tao, Minfang
Jia, Weiping
author_facet Zhao, Weijing
Pan, Jiemin
Li, Huaping
Huang, Yajuan
Liu, Fang
Tao, Minfang
Jia, Weiping
author_sort Zhao, Weijing
collection PubMed
description AIMS: Serum cystatin C (CysC) has recently been shown to be associated with the incidence of type 2 diabetes mellitus (T2DM) and progression to the pre-diabetic state. The aim of this study was to explore the relationship between serum CysC and the risk of gestational diabetes mellitus (GDM) in Chinese pregnant women. METHODS: This cross-sectional study consisted of 400 pregnant women including111 with GDM and 289 with normal glucose tolerance at 24–28 weeks of gestation. The subjects were further divided into four groups according to the CysC quartiles, and their clinical characteristics were compared. The serum CysC concentration was measured using immunoturbidimetry and the degree of insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Serum CysC levels were significantly higher in pregnant women with GDM than in the healthy pregnant women[1.0(0.8–1.8) vs 0.7(0.6–1.0), P<0.01). The Spearman’s correlation analysis showed that serum CysC was positively associated with HOMA-IR(r = 0.118, P<0.05) and the occurrence of GDM(r = 0.348, P<0.01). The pregnant women were divided into quartiles according to their serum CysC concentrations. Compared to the first quartile, pregnant women in Q2 (OR, 2.441; P = 0.025), Q3 (OR, 3.383; P = 0.001) and Q4 (OR, 5.516; P<0.001) had higher risk of GDM after adjusted for age, BMI, HbA1c and HOMA-IR. Further, with a rise in the serum CysC, there was an increasing trend in the HOMA-IR levels (P<0.05). A binary logistic regression analysis after adjusting for other confounding variables revealed a significant and independent association between serum CysC and GDM [OR = 14.269; 95% confidence interval, 4.977–40.908, P<0.01].The receiver operating characteristic curve analysis revealed that the optimal cutoff point for serum CysC to indicate GDM was 0.95mg/L. CONCLUSIONS: Serum CysC is significantly and independently associated with insulin resistance and GDM. It may be a helpful biomarker to identify the risk of GDM in Chinese pregnant women.
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spelling pubmed-47439262016-02-11 Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus Zhao, Weijing Pan, Jiemin Li, Huaping Huang, Yajuan Liu, Fang Tao, Minfang Jia, Weiping PLoS One Research Article AIMS: Serum cystatin C (CysC) has recently been shown to be associated with the incidence of type 2 diabetes mellitus (T2DM) and progression to the pre-diabetic state. The aim of this study was to explore the relationship between serum CysC and the risk of gestational diabetes mellitus (GDM) in Chinese pregnant women. METHODS: This cross-sectional study consisted of 400 pregnant women including111 with GDM and 289 with normal glucose tolerance at 24–28 weeks of gestation. The subjects were further divided into four groups according to the CysC quartiles, and their clinical characteristics were compared. The serum CysC concentration was measured using immunoturbidimetry and the degree of insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Serum CysC levels were significantly higher in pregnant women with GDM than in the healthy pregnant women[1.0(0.8–1.8) vs 0.7(0.6–1.0), P<0.01). The Spearman’s correlation analysis showed that serum CysC was positively associated with HOMA-IR(r = 0.118, P<0.05) and the occurrence of GDM(r = 0.348, P<0.01). The pregnant women were divided into quartiles according to their serum CysC concentrations. Compared to the first quartile, pregnant women in Q2 (OR, 2.441; P = 0.025), Q3 (OR, 3.383; P = 0.001) and Q4 (OR, 5.516; P<0.001) had higher risk of GDM after adjusted for age, BMI, HbA1c and HOMA-IR. Further, with a rise in the serum CysC, there was an increasing trend in the HOMA-IR levels (P<0.05). A binary logistic regression analysis after adjusting for other confounding variables revealed a significant and independent association between serum CysC and GDM [OR = 14.269; 95% confidence interval, 4.977–40.908, P<0.01].The receiver operating characteristic curve analysis revealed that the optimal cutoff point for serum CysC to indicate GDM was 0.95mg/L. CONCLUSIONS: Serum CysC is significantly and independently associated with insulin resistance and GDM. It may be a helpful biomarker to identify the risk of GDM in Chinese pregnant women. Public Library of Science 2016-02-05 /pmc/articles/PMC4743926/ /pubmed/26849560 http://dx.doi.org/10.1371/journal.pone.0147277 Text en © 2016 Zhao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhao, Weijing
Pan, Jiemin
Li, Huaping
Huang, Yajuan
Liu, Fang
Tao, Minfang
Jia, Weiping
Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus
title Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus
title_full Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus
title_fullStr Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus
title_full_unstemmed Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus
title_short Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus
title_sort relationship between high serum cystatin c levels and the risk of gestational diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743926/
https://www.ncbi.nlm.nih.gov/pubmed/26849560
http://dx.doi.org/10.1371/journal.pone.0147277
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