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Blockage of the Ryanodine Receptor via Azumolene Does Not Prevent Mechanical Ventilation-Induced Diaphragm Atrophy

Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm muscle atrophy, and diaphragmatic weakness may contribute to difficult weaning from MV. Therefore, developing a therapeutic countermeasure to...

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Detalles Bibliográficos
Autores principales: Talbert, Erin E., Smuder, Ashley J., Kwon, Oh Sung, Sollanek, Kurt J., Wiggs, Michael P., Powers, Scott K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744044/
https://www.ncbi.nlm.nih.gov/pubmed/26849371
http://dx.doi.org/10.1371/journal.pone.0148161