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Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions

Ephs are transmembrane receptors that mediate cell-cell signaling. The N-terminal ectodomain binds ligands and enables receptor clustering, which activates the intracellular kinase. Relatively little is known about the function of the membrane-proximal fibronectin domain 2 (FN2) of the ectodomain. M...

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Detalles Bibliográficos
Autores principales: Chavent, Matthieu, Seiradake, Elena, Jones, E. Yvonne, Sansom, Mark S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744086/
https://www.ncbi.nlm.nih.gov/pubmed/26724997
http://dx.doi.org/10.1016/j.str.2015.11.008