Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

Mutational hotspots indicate selective pressure across a population of tumor samples, but their prevalence within and across cancer types is incompletely characterized. An approach to detect significantly mutated residues, rather than methods that identify recurrently mutated genes, may uncover new...

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Detalles Bibliográficos
Autores principales: Chang, Matthew T., Asthana, Saurabh, Gao, Sizhi Paul, Lee, Byron H., Chapman, Jocelyn S., Kandoth, Cyriac, Gao, JianJiong, Socci, Nicholas D., Solit, David B., Olshen, Adam B., Schultz, Nikolaus, Taylor, Barry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744099/
https://www.ncbi.nlm.nih.gov/pubmed/26619011
http://dx.doi.org/10.1038/nbt.3391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744099/
https://www.ncbi.nlm.nih.gov/pubmed/26619011
http://dx.doi.org/10.1038/nbt.3391

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