Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats

OBJECTIVE(S): Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test. MATERIALS AND METHODS: Orexin-A...

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Detalles Bibliográficos
Autores principales: Ghasemi, Elmira, Heidari-Oranjaghi, Nima, Azhdari-Zarmehri, Hassan, Sadegh, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744357/
https://www.ncbi.nlm.nih.gov/pubmed/26877847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744357/
https://www.ncbi.nlm.nih.gov/pubmed/26877847

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