A biophysical model of supercoiling dependent transcription predicts a structural aspect to gene regulation

BACKGROUND: Transcription in Escherichia coli generates positive supercoiling in the DNA, which is relieved by the enzymatic activity of gyrase. Recently published experimental evidence suggests that transcription initiation and elongation are inhibited by the buildup of positive supercoiling. It ha...

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Detalles Bibliográficos
Autores principales: Bohrer, Christopher H., Roberts, Elijah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744432/
https://www.ncbi.nlm.nih.gov/pubmed/26855771
http://dx.doi.org/10.1186/s13628-016-0027-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744432/
https://www.ncbi.nlm.nih.gov/pubmed/26855771
http://dx.doi.org/10.1186/s13628-016-0027-0

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