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A biophysical model of supercoiling dependent transcription predicts a structural aspect to gene regulation
BACKGROUND: Transcription in Escherichia coli generates positive supercoiling in the DNA, which is relieved by the enzymatic activity of gyrase. Recently published experimental evidence suggests that transcription initiation and elongation are inhibited by the buildup of positive supercoiling. It ha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744432/ https://www.ncbi.nlm.nih.gov/pubmed/26855771 http://dx.doi.org/10.1186/s13628-016-0027-0 |