Formation of the Δ(18,19) Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase‐like Enzyme

Salinomycin is a widely used polyether coccidiostat and was recently found to have antitumor activities. However, the mechanism of its biosynthesis remained largely speculative until now. Reported herein is the identification of an unprecedented function of SlnM, homologous to O‐methyltransferases,...

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Detalles Bibliográficos
Autores principales: Jiang, Chunyan, Qi, Zhen, Kang, Qianjin, Liu, Jing, Jiang, Ming, Bai, Linquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744726/
https://www.ncbi.nlm.nih.gov/pubmed/26096919
http://dx.doi.org/10.1002/anie.201503561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744726/
https://www.ncbi.nlm.nih.gov/pubmed/26096919
http://dx.doi.org/10.1002/anie.201503561

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