A Novel PET Imaging Probe for the Detection and Monitoring of Translocator Protein 18 kDa Expression in Pathological Disorders

A new fluorine-substituted ligand, compound 1 (CB251), with a very high affinity (Ki = 0.27 ± 0.09 nM) and selectivity for the 18-kDa translocator protein (TSPO), is presented as an attractive biomarker for the diagnosis of neuroinflammation, neurodegeneration and tumour progression. To test compoun...

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Detalles Bibliográficos
Autores principales: Perrone, Mara, Moon, Byung Seok, Park, Hyun Soo, Laquintana, Valentino, Jung, Jae Ho, Cutrignelli, Annalisa, Lopedota, Angela, Franco, Massimo, Kim, Sang Eun, Lee, Byung Chul, Denora, Nunzio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745082/
https://www.ncbi.nlm.nih.gov/pubmed/26853260
http://dx.doi.org/10.1038/srep20422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745082/
https://www.ncbi.nlm.nih.gov/pubmed/26853260
http://dx.doi.org/10.1038/srep20422

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