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Rituximab Downregulates Gene Expression Associated with Cell Proliferation, Survival, and Proteolysis in the Peripheral Blood from Rheumatoid Arthritis Patients: A Link between High Baseline Autophagy-Related ULK1 Expression and Improved Pain Control

Objective. To clarify molecular mechanisms for the response to rituximab in a longitudinal study. Methods. Peripheral blood from 16 RA patients treated with rituximab for a single treatment course and 26 healthy controls, blood and knee articular cartilages from 18 patients with long-standing RA, an...

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Detalles Bibliográficos
Autores principales: Tchetina, Elena V., Pivanova, Anastasya N., Markova, Galina A., Lukina, Galina V., Aleksandrova, Elena N., Aleksankin, Andrey P., Makarov, Sergey A., Kuzin, Aleksandr N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745296/
https://www.ncbi.nlm.nih.gov/pubmed/27057353
http://dx.doi.org/10.1155/2016/4963950