JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression

The relative contributions of the JNK subtypes in inflammatory β-cell failure and apoptosis are unclear. The JNK protein family consists of JNK1, JNK2, and JNK3 subtypes, encompassing many different isoforms. INS-1 cells express JNK1α1, JNK1α2, JNK1β1, JNK1β2, JNK2α1, JNK2α2, JNK3α1, and JNK3α2 mRNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Prause, Michala, Mayer, Christopher Michael, Brorsson, Caroline, Frederiksen, Klaus Stensgaard, Billestrup, Nils, Størling, Joachim, Mandrup-Poulsen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745310/
https://www.ncbi.nlm.nih.gov/pubmed/26962537
http://dx.doi.org/10.1155/2016/1312705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745310/
https://www.ncbi.nlm.nih.gov/pubmed/26962537
http://dx.doi.org/10.1155/2016/1312705

Ejemplares similares