PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1

Ewing sarcoma (ES) is the second most frequent bone cancer in childhood and is characterized by the presence of the balanced translocation t(11;22)(q24;q12) in more than 85% of cases, generating a dysregulated transcription factor EWS/FLI1. This fusion protein is an essential oncogenic component of...

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Detalles Bibliográficos
Autores principales: Giorgi, Chiara, Boro, Aleksandar, Rechfeld, Florian, Lopez-Garcia, Laura A., Gierisch, Maria E., Schäfer, Beat W., Niggli, Felix K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745699/
https://www.ncbi.nlm.nih.gov/pubmed/26336820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745699/
https://www.ncbi.nlm.nih.gov/pubmed/26336820

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