CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Cathepsins S (CatS) has been implicated in numerous tumourigenic processes and here we document for the first time its involvement in CCL2 regulation within the tumour microenvironment. Analysis of syngeneic tumours highlighted reduced infiltrating macrophages in CatS depleted tumours. Interrogation...

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Detalles Bibliográficos
Autores principales: Wilkinson, Richard D.A., Magorrian, Sinead M., Williams, Rich, Young, Andrew, Small, Donna M., Scott, Christopher J., Burden, Roberta E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745758/
https://www.ncbi.nlm.nih.gov/pubmed/26358505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745758/
https://www.ncbi.nlm.nih.gov/pubmed/26358505

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