Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H(2)O(2) generation: antagonism by tetrathiomolybdate

HIGHLIGHTS: exogenous SOD increases apoptosis by sub-toxic disulfiram without copper overload. H(2)O(2) generation from glucose oxidase also potentiates disulfiram toxicity. N-acetylcysteine suppresses antitumor potentiation of DSF by H(2)O(2) generation; sub-toxic tetrathiomolybdate inhibits potent...

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Detalles Bibliográficos
Autores principales: Calderon-Aparicio, Ali, Strasberg-Rieber, Mary, Rieber, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745761/
https://www.ncbi.nlm.nih.gov/pubmed/26356671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745761/
https://www.ncbi.nlm.nih.gov/pubmed/26356671

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