Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

The immunoglobulin heavy-chain variable region (IGHV) mutational status is a strong determinant of remission duration in chronic lymphocytic leukemia (CLL). The aim of this work was to compare the multidrug resistance (MDR) signature of IGHV mutated and unmutated CLL cells, identifying biochemical a...

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Detalles Bibliográficos
Autores principales: Rigoni, Micol, Riganti, Chiara, Vitale, Candida, Griggio, Valentina, Campia, Ivana, Robino, Marta, Foglietta, Myriam, Castella, Barbara, Sciancalepore, Patrizia, Buondonno, Ilaria, Drandi, Daniela, Ladetto, Marco, Boccadoro, Mario, Massaia, Massimo, Coscia, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745766/
https://www.ncbi.nlm.nih.gov/pubmed/26284584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745766/
https://www.ncbi.nlm.nih.gov/pubmed/26284584

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