All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype

Hutchinson Gilford progeria syndrome is a fatal disorder characterized by accelerated aging, bone resorption and atherosclerosis, caused by a LMNA mutation which produces progerin, a mutant lamin A precursor. Progeria cells display progerin and prelamin A nuclear accumulation, altered histone methyl...

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Detalles Bibliográficos
Autores principales: Pellegrini, Camilla, Columbaro, Marta, Capanni, Cristina, D'Apice, Maria Rosaria, Cavallo, Carola, Murdocca, Michela, Lattanzi, Giovanna, Squarzoni, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745772/
https://www.ncbi.nlm.nih.gov/pubmed/26359359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745772/
https://www.ncbi.nlm.nih.gov/pubmed/26359359

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