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All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
Hutchinson Gilford progeria syndrome is a fatal disorder characterized by accelerated aging, bone resorption and atherosclerosis, caused by a LMNA mutation which produces progerin, a mutant lamin A precursor. Progeria cells display progerin and prelamin A nuclear accumulation, altered histone methyl...
Autores principales: | Pellegrini, Camilla, Columbaro, Marta, Capanni, Cristina, D'Apice, Maria Rosaria, Cavallo, Carola, Murdocca, Michela, Lattanzi, Giovanna, Squarzoni, Stefano |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745772/ https://www.ncbi.nlm.nih.gov/pubmed/26359359 |
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