Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

Oncogenesis in non-small cell lung cancer (NSCLC) is regulated by a complex signal transduction network. Single-agent targeted therapy fails frequently due to treatment insensitivity and acquired resistance. In this study, we demonstrate that co-inhibition of the MAPK and SRC pathways using a PD0325...

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Detalles Bibliográficos
Autores principales: Chua, Kian Ngiap, Kong, Li Ren, Sim, Wen Jing, Ng, Hsien Chun, Ong, Weijie Richard, Thiery, Jean Paul, Huynh, Hung, Goh, Boon Cher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745777/
https://www.ncbi.nlm.nih.gov/pubmed/26358373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745777/
https://www.ncbi.nlm.nih.gov/pubmed/26358373

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