CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants

The vast majority of disease-associated single nucleotide polymorphisms (SNPs) mapped by genome-wide association studies (GWAS) are located in the non-protein coding genome, but establishing the functional and mechanistic roles of these sequence variants has proven challenging. Here, we describe a g...

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Detalles Bibliográficos
Autores principales: Spisak, Sandor, Lawrenson, Kate, Fu, Yanfang, Csabai, Istvan, Cottman, Rebecca T., Haiman, Christopher, Han, Ying, Seo, Ji-Heui, Lenci, Romina, Li, Qiyuan, Tisza, Viktoria, Szallasi, Zoltan, Herbert, Zachery T., Chabot, Matthew, Pomerantz, Mark, Solymosi, Norbert, Gayther, Simon, Joung, J. Keith, Freedman, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746056/
https://www.ncbi.nlm.nih.gov/pubmed/26398868
http://dx.doi.org/10.1038/nm.3975

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