The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression

Protein arginine methyltransferase 6 (PRMT6) catalyses asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), which has been shown to impede the deposition of histone H3 lysine 4 trimethylation (H3K4me3) by blocking the binding and activity of the MLL1 complex. Importantly, the genomic occ...

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Detalles Bibliográficos
Autores principales: Stein, Claudia, Nötzold, René Reiner, Riedl, Stefanie, Bouchard, Caroline, Bauer, Uta-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746130/
https://www.ncbi.nlm.nih.gov/pubmed/26848759
http://dx.doi.org/10.1371/journal.pone.0148892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746130/
https://www.ncbi.nlm.nih.gov/pubmed/26848759
http://dx.doi.org/10.1371/journal.pone.0148892

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