A molecular nanodevice for targeted degradation of mRNA during protein synthesis

RNase H is an endonuclease that catalyzes the cleavage of RNA. Because it only acts on RNA in RNA:DNA hybrids, RNase H can be used for targeted degradation of RNA when used in combination with antisense oligodeoxyribonucleotides (ASODNs) designed against a specific sequence of the target RNA. In thi...

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Detalles Bibliográficos
Autores principales: Lee, Kyung-Ho, Min, Seung-Eui, Kim, Haseong, Lee, Seung-Goo, Kim, Dong-Myung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746582/
https://www.ncbi.nlm.nih.gov/pubmed/26857021
http://dx.doi.org/10.1038/srep20733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746582/
https://www.ncbi.nlm.nih.gov/pubmed/26857021
http://dx.doi.org/10.1038/srep20733

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