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Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance
Bif-1 is a membrane-curvature inducing protein that is implicated in the regulation of autophagy and tumorigenesis. Here, we report that Bif-1 plays a critical role in regulating lipid catabolism to control the size of lipid droplets and prevent the development of obesity and insulin resistance upon...
Autores principales: | Liu, Ying, Takahashi, Yoshinori, Desai, Neelam, Zhang, Jun, Serfass, Jacob M., Shi, Yu-Guang, Lynch, Christopher J., Wang, Hong-Gang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746598/ https://www.ncbi.nlm.nih.gov/pubmed/26857140 http://dx.doi.org/10.1038/srep20453 |
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