SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD(+)-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human SIRT6 has a direct role in maintaining the homeostasis of mesodermal tissues. To this...

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Detalles Bibliográficos
Autores principales: Pan, Huize, Guan, Di, Liu, Xiaomeng, Li, Jingyi, Wang, Lixia, Wu, Jun, Zhou, Junzhi, Zhang, Weizhou, Ren, Ruotong, Zhang, Weiqi, Li, Ying, Yang, Jiping, Hao, Ying, Yuan, Tingting, Yuan, Guohong, Wang, Hu, Ju, Zhenyu, Mao, Zhiyong, Li, Jian, Qu, Jing, Tang, Fuchou, Liu, Guang-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746611/
https://www.ncbi.nlm.nih.gov/pubmed/26768768
http://dx.doi.org/10.1038/cr.2016.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746611/
https://www.ncbi.nlm.nih.gov/pubmed/26768768
http://dx.doi.org/10.1038/cr.2016.4

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