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One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

Pig shows multiple superior characteristics in anatomy, physiology, and genome that have made this species to be more suitable models for human diseases, especially for neurodegenerative diseases, because they have similar cerebral convolutions compared with human neocortex. Recently, CRISPR/Cas9 sy...

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Detalles Bibliográficos
Autores principales: Wang, Xianlong, Cao, Chunwei, Huang, Jiaojiao, Yao, Jing, Hai, Tang, Zheng, Qiantao, Wang, Xiao, Zhang, Hongyong, Qin, Guosong, Cheng, Jinbo, Wang, Yanfang, Yuan, Zengqiang, Zhou, Qi, Wang, Hongmei, Zhao, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746670/
https://www.ncbi.nlm.nih.gov/pubmed/26857844
http://dx.doi.org/10.1038/srep20620